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Computational Biology

The Computational Biology platform supports users in defining the experimental design and provides management, analysis and statistical modeling services of high throughput data.

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Instruments

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MACHINA HPC cluster

The MACHINA HPC cluster includes 376 cores equipped with 7631,9 GB of RAM distributed on 21 blades and more than 100 TB of storage. MACHINA includes both GPU nodes and nodes with 2TB of RAM, allowing a large spectrum of applications from Machine Learning to the assembly of complex genomes

Services

Genomics and metagenomics
  • Genome assembly and annotation
  • Development of genotyping arrays (Illumina/Affymetrix)
  • Resequencing data analysis (SNP discovery, GBS, SPET, comparativa)
  • Analysis of amplicon metagenomic data (16S, ITS)
  • Assembly and annotation of shotgun metagenomic data
Transriptomics
  • Transcriptomic assembly and functional annotation
  • Differential expression analysis
  • Functional enrichment analysis
  • Unsupervised analysis (clustering, PCA)
Metabolomics
  • Pre-processing of targeted and untargeted metabolomics datasets (NMR and LC-MS)

Applications

Agriculture
  • Genomics of plants, insects, fungi, bacteria and viruses 
  • Gene expression analysis in biotic or abiotic stress
  • Plant-pathogen interactions
  • Support to marker assisted breeding
Biodiversity analysis 
  • Analysis of microbial communities
  • Genomic variability of natural populations
Agrifood 
  • Metagenomic and metabolomic analysis of fermented products
  • Traceability 
  • Food security and quality
  • Host-associated microbiomes (human, animal or plants)