(HEU Horizon Europe 21-27) Bryophytes, including mosses and liverworts, have long been overlooked in the world of biotechnology. However, these ancient plants hold a treasure trove of biologically active compounds (BACs) with immense potential for bioeconomy. The BRYOMOLECULES project, a groundbreaking research initiative funded by the European Union within the Horizon Europe program, aims to explore and harness this potential, driving innovation in the cosmetics and pharmaceutical industries. 

The BRYOMOLECULES project employs cutting-edge biotechnological approaches. By establishing innovative methods for cultivating bryophytes and engineering their metabolic pathways in controlled environments, the project aims to produce high-value BACs without relying on overharvesting natural populations. This dual strategy not only ensures a steady supply of these valuable compounds but also aligns with the European Union’s commitment to environmental sustainability and resource efficiency, paving the way for a greener, more sustainable bioeconomy. 

Over the next three years, BRYOMOLECULES will provide groundbreaking insights into the vast untapped potential of European bryophytes, making significant contributions towards the European Green Deal, namely by: 

• Advancing knowledge of European bryophytes and how they can be used in bioeconomic development, particularly in the cosmetic and pharmaceutical sectors; 
• Developing innovative biotechnological methods to produce BACs, enabling new, greener biochemical routes that contribute to decreasing environmental impact; 
• Driving economic growth by creating new, marketable, and patentable bio-based innovations that will support the development of sustainable industries in Europe, contributing to the circular economy; 
• Engaging the public through educational initiatives to raise awareness about the ecological and economic value of bryophytes; 
• Promoting the valorisation of the biotechnological capacity of European bryophytes by providing alternative methods for producing BACs, and at the same time reducing the pressure on natural populations by promoting conservation and preventing biodiversity loss; 
• Active collaboration between academic and industrial partners, enhancing the competitiveness of European biotech companies and BAC producers. This collaborative approach will drive innovation and ensure that Europe remains at the forefront of bioeconomic development. 

The ultimate goal of the BRYOMOLECULES project is to unlock the biotechnological potential of European bryophytes and support a transition to a greener, more sustainable economy. 

(EU HORIZON) The project MICROBES-4-CLIMATE will provide a wider community of users/researchers, irrespective of location, efficient access to a cluster of complementary world-class Research Infrastructures and their integrated, advanced services along with training and scientific and/or technical support, to address such need. An excellence-driven programme of Transnational Access, which is at the core of the project, will enable users to conduct curiosity-driven research addressing terrestrial biodiversity and ecosystems, in light of the abovementioned multidimensional and still poorly understood microbiomes-plants-soil-environment interactions, and its roles in CG responses, resilience, and mitigation. This will foster the advancement of frontier knowledge and also pave the way to applied research on harnessing plant-microbiome interactions to improve the climate resiliency of plants/crops and to enable e.g., precision, sustainable and resilient agriculture.

(Fondazione VRT) - Obiettivo generale del progetto è lo sviluppo di metodi per l’identificazione e la certificazione di specie della flora selvatica del Trentino a rilevanza economica nei settori della cosmesi, erboristeria e farmaceutica. Il progetto è supportato dalla Voxal Corporation, una ditta Trentina specializzata nel settore della cosmeceutica e della biologia vegetale; svolge attività di ricerca, sviluppo tecnologico collaborazione con istituiti clinici, poli universitari, cooperative, associazioni ed aziende per la creazione di formulazioni innovative. Se approvato nel corso del progetto verranno cercate altre collaborazioni con ditte trentine nel settore dell’erboristeria e della cosmetica.

Attività FEM: Nell’ambito del progetto verranno raccolte e analizzate con metodi di sequenziamento Illumina (Rad-Seq e sequenziamento whole genome a bassa profondità) una selezione di specie officinali del territorio Trentino e di altre regioni per verificarne la variazione genetica. Per ciascuna specie verranno raccolti fino ad un massimo di 5 individui per area geografica in modo da studiarne la variazione genetica inter- ed intra-popolazione. I due metodi di analisi verranno messi a confronto per definire quale fornisce il miglior compromesso costi/benefici per l’identificazione a livello specifico e di popolazioni. Il metodo con la più elevata capacità di discriminazione verrà ulteriormente valutato per lo sviluppo di certificazione di origine genetica della materie prime di origine vegetale in prodotti cosmetici, farmaceutici ed erboristici.